O conhecimento adquirido e gerado no nosso laboratório é divulgado na forma de capítulos de livros, depósito de patentes e publicações em revistas científicas.
Capítulos de livros
ISHIDA, K.Agentes Antifúngicos. In:TRABULSI, K.R.; ALTERTHUMF. Microbiologia. 6ª. Edição, Atheneu, São Paulo, p. 609-618, 2015.
Patentes
STEFANI HA, ISHIDA K, ARGOMEDOLMZ, BARBEIRO CS. Compostos derivados de 2-oxazolina, compostosderivados do ácido naftoico, processo sintético de obtenção e uso de compostos derivados de 2-oxazolina.BR 10 2017 023661 7, Título: Compostos derivados de 2-oxazolina, compostosderivados do ácido naftoico, processo sintético de obtenção e uso de compostos derivados de 2-oxazolina. Instituição de registro: INPI - Instituto Nacional da Propriedade Industrial, Data da solicitação do depósito: 01/11/2017
ISHIDA, K.; SPADARI, C.C.; LOPES, L.B.; DE BASTIANI, F.W.M.S. Formulação farmacêutica, processo para preparação da formulação farmacêutica, e uso da mesma. Brasil. Registro: BR1020170180115, Título: “Formulação farmacêutica, processo para preparação da formulação farmacêutica, e uso da mesma”, Instituição de registro: INPI - Instituto Nacional da Propriedade Industrial, Data da solicitação do depósito: 23/08/2017
JANSEN, J.U.; DIAS, L.S.; ISHIDA, K.; Lincopan, N. Solução antimicrobiana aditivada e seu uso. Brasil.Registro: BR1020170036839, Título: "Solução antimicrobiana aditivada e seu uso", Instituição de registro: INPI - Instituto Nacional da Propriedade Industrial, Data da solicitação do depósito: 22/02/2017
Artigos Científicos
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32. FREITAS, A.L.D.; KAPLUM, V.; ROSSI, D.C.P.; DA SILVA, L.B.R.; MELHEM, M.S.C.; TABORDA, C.P.; MELLO, J.C.P.; NAKAMURA, C.V.; ISHIDA, K. Proanthocyanidin polymeric tannins from Stryphnodendron adstringens are effective against Candida spp. isolates and for vaginal candidiasis treatment. Journal of Ethnopharmacology, v. 216, p. 184–190, 2018.
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31. MIGOTTO, A.; CARVALHO, V. F.M.; SALATA, G.; DA SILVA, F. W. M.; YAN, C. Y. I.; ISHIDA, K.; COSTA-LOTUFO, L.; STEINER, A.A.; LOPES, L.B. Multifunctional nanoemulsions for intraductal delivery as a new platform for treatment of breast cancer. Drug Delivery, 2018.
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30. ROSSI, D. C. P.; SPADARI, C.C.; NOSANCHUCK, J. D.; TABORDA, C. P.; ISHIDA, K.Miltefosine is fungicidal to Paracoccidioides spp. yeast cells but sub- inhibitory concentrations induce melanization. International Journal of Antimicrobial Agents (Print), v.49, p.465 - 471, 2017.
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29. SPADARI, CRISTINA DE CASTRO; LOPES, LUCIANA B.; ISHIDA, KELLY.Potential Use of Alginate-Based Carriers As Antifungal Delivery System. Frontiers in Microbiology (Online), v.8, p.1 - 11, 2017.
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28. ISHIDA, K.; CASTRO, R. A.; TORRADO, J. J.; SERRANO, D. R.; BORBA-SANTOS, L. P.; QUINTELA, L. P.; DE SOUZA, W.; ROZENTAL, S.; LOPES-BEZERRA, L. M.Efficacy of a poly-aggregated formulation of amphotericin B in treating systemic sporotrichosis caused by Sporothrix brasiliensis. MEDICAL MYCOLOGY, myx040, 2017.
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27. VILA, T.V.M.; FONSECA, B.B.; CUNHA, M.M.L.; SANTOS, G. R. C.; ISHIDA, KELLY; BERGTER, E. B.; DE SOUZA, W.; ROZENTAL, S.Candida albicans biofilms: comparative analysis of room-temperature and cryo-fixation for scanning electron microscopy. Journal of Microscopy, 2017.
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26. MUÑOZ, JULIAN E.; ROSSI, DIEGO C. P.; ISHIDA, KELLY; SPADARI, CRISTINA C.; MELHEM, MARCIA S. C.; GARCIA, DANIEL M.; CAIRES, ANTONIO C. F.; TABORDA, CARLOS P.; RODRIGUES, ELAINE G. Antifungal Activity of the Biphosphinic Cyclopalladate C7a against Candida albicans Yeast Forms In Vitro and In Vivo. Frontiers in Microbiology, v.8, p.1 - 10, 2017.
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25. BONILLA JJA; GUERRERO, DJP; SUAREZ CIS; SAEZ, RGT; ISHIDA, K.; FONSECA, BB; ROZENTAL, S.; LOPEZ, CCOGreen synthesis of silver nanoparticles using maltose and cysteine and their effect on cell wall envelope shapes and microbial growth of Candida spp. Journal of Nanoscience and Nanotechnology (Print), v.17, p. 1729 - 1739, 2017.
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24. BORBA-SANTOS, L. P.; ISHIDA, K.; CALOGEROPOULOU, T.; DE SOUZA, W.; ROZENTAL, S. Adamantylidene-substituted alkylphosphocholine TCAN26 is more active against Sporothrix schenckii than miltefosine. Memórias do Instituto Oswaldo Cruz (Online), p.1 - 5, 2016.
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23. BOATTO, H. F.; CAVALCANTI, S. D. B.; DEL NEGRO, G. M. B.; GIRAO, M. J. B. C.; FRANCISCO, E. C.; ISHIDA, K.; GOMPERTZ, O. F.Candida duobushaemulonii: an emerging rare pathogenic yeast isolated from recurrent vulvovaginal candidiasis in Brazil. Memórias do Instituto Oswaldo Cruz (Online), v.111, p.407 - 410, 2016.
22. BORBA-SANTOS, L. P.; VISBAL, G.; Braga TG; RODRIGUES, A. M.; CAMARGO, Z. P.; LOPES- BEZERRA, L.M.; ISHIDA, K.; SOUZA, W.; ROZENTAL, S.Inhibition of Delta-24-sterol methyltransferase reduces growth of Sporothrix schenckii and Sporothrix brasiliensis. Frontiers in Microbiology (Online). , v.7, p.1 - 13, 2016.
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21. VILA, T. V. M.; ISHIDA, K.; SEABRA, S. H.; ROZENTAL, S.Miltefosine inhibits Candida albicans and non-albicans Candida spp. biofilms and impairs the dispersion of infectious cells. International Journal of Antimicrobial Agents (Print). , v.48, p.512 - 520, 2016.
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20. LUIZ, R. L. F.; VILA, T.V.M.; MELLO, J. C. P.; NAKAMURA, C. V.; ROZENTAL, S.; ISHIDA, K. Proanthocyanidins polymeric tannin from Stryphnodendron adstringens are active against Candida albicans biofilms. BMC Complementary and Alternative Medicine (Online), v. 15, p. 68-78, 2015.
19. BORBA-SANTOS, L. P.; GAGINI, T.; ISHIDA, K.; DE SOUZA, W.; ROZENTAL, S. Miltefosine is active against Sporothrix brasiliensis isolates with in vitro low susceptibility to amphotericin B or itraconazole. Journal of Medical Microbiology, v. Fev, p. 1, 2015.
18. ISHIDA, K. ; CASTRO, R. A. ; SANTOS, L. P. B. ; QUINTELLA, L. ; LOPES-BEZERRA, L.M. ; ROZENTAL, S. . Amphotericin B, alone or followed by itraconazole therapy, is effective in the control of experimental disseminated sporotrichosis by Sporothrix brasiliensis. Medical Mycology (Oxford. Print), v. 53, p. 34-41, 2015.
17. BORBA-SANTOS, L. P. ; RODRIGUES, A. M. ; GAGINI, T. B. ; FERNANDES, G. F. ; CASTRO, R. ; DE CAMARGO, Z. P. ; NUCCI, M. ; LOPES-BEZERRA, L. M. ; ISHIDA, K. ; ROZENTAL, S. . Susceptibility of Sporothrix brasiliensis isolates to amphotericin B, azoles, and terbinafine. Medical Mycology (Oxford. Online), v. 53, p. 178-188, 2015.
16. ISHIDA, K. ; CIPRIANO T ; ROCHA, G.M. ; WEISSMÜLLER, G. ; GOMES, F. ; MIRANDA, K. ; ROZENTAL, S. . Silver nanoparticle production by the fungus Fusarium oxysporum: nanoparticle characterisation and analysis of antifungal activity against pathogenic yeasts. Memórias do Instituto Oswaldo Cruz (Impresso), v. 108, p. 1-9, 2014.
15. VILA, T. V. M. ; ISHIDA, K. ; DE SOUZA, W. ; PROUSIS, K. ; CALOGEROPOULOU, T. ; ROZENTAL, S. . Effect of alkylphospholipids on Candida albicans biofilm formation and maturation. Journal of Antimicrobial Chemotherapy (Online), v. 68, p. 113-125, 2013.
14. ISHIDA, K. ; UEDA-YAMAGUCHI, M. ; Yamada-Ogatta, S.F. ; UEDA-NAKAMURA, T. ; SVIDZINSKI, T.I.E. ; NAKAMURA, C. V. . Characterization of Candida spp. isolated from vaginal fluid: identification, antifungal susceptibility, and virulence profile. Acta Scientiarum. Health Sciences (Online), v. 35, p. 1-8, 2013.
13. ISHIDA, K., UEDA-YAMAGUCHI, M., UEDA-NAKAMURA, T., DIAS FILHO, B. P., Yamada-Ogatta, S.F., NAKAMURA, C. V. Performance of methods for identification of yeasts isolated from blotted water: High prevalence of Candida parapsilosis. Semina. Ciências Biológicas e da Saúde (Online), v.34, p.205-214, 2013.
12. COTTA SR ; MOTA FF ; TUPINAMBÁ G ; ISHIDA, K. ; ROZENTAL, S. ; SILVA, D.O. ; SILVA, A.J.R. ; ALVIANO, D. S. ; SELDIN, L. . Antimicrobial activity of Paenibacillus kribbensis POC 115 against the dermatophyte Trichophyton rubrum. World Journal of Microbiology & Biotechnology Incorporating the MIRCEN Journal of Applied Microbiology and Biotechnology (Dordrecht. Online), v. 28, p. 953-962, 2012.
11. GUERRA, C. R. ; ISHIDA, K. ; NUCCI, M.L.M. ; ROZENTAL, S. . Terbinafine inhibits Cryptococcus neoformans growth and modulates fungal morphology. Memórias do Instituto Oswaldo Cruz (Impresso), v. 107, p. 582-590, 2012.
10. ISHIDA, K. ; ALVIANO, D. S. ; Silva, B.G. ; GUERRA, C. R. ; COSTA, A. S. ; NUCCI, M.L.M. ; ALVIANO, C.S. ; ROZENTAL, S. . Negative correlation between phospholipase and esterase activity produced by Fusarium isolates. Brazilian Journal of Medical and Biological Research on line, v. 45, p. 411-416, 2012.
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9. ISHIDA, K. ; VISBAL, G. ; RODRIGUES, J. C. F. ; URBINA, J.A. ; SOUZA, W. ; ROZENTAL, S. . Two squalene synthase inhibitors, E5700 and ER-119884, interfere with cellular proliferation and induce ultrastructural and lipid profile alterations in a Candida tropicalis strain resistant to fluconazole, itraconazole and amphotericin B.. Journal of Infection and Chemotherapy, v. 17, p. 563-570, 2011.
8. ISHIDA, K. ; RODRIGUES, J. C. F. ; CAMMERER, S. ; URBINA, J.A. ; GILBERT, I. ; SOUZA, W. ; ROZENTAL, S. . Synthetic arylquinuclidine derivatives exhibit antifungal activity against Candida albicans, Candida tropicalis and Candida parapsilopsis.. Annals of Clinical Microbiology and Antimicrobials, v. 10, p. 3-12, 2011.
7. COSTA, MA ; ISHIDA, K. ; BRAGA, C. F. S. ; KAPLUM, V. ; KOSLYK, EDA ; Mello, J C P ; NAKAMURA, T. U. ; DIAS FILHO, B. P. ; NAKAMURA, C. V. . Safety evaluation of proanthocyanidin polymer-rich fraction obtained from stem bark of Stryphnodendron adstringens (BARBATIMÃO) for use as a pharmacological agent. Regulatory Toxicology and Pharmacology, v. xx, p. x-x, 2010.
6. ISHIDA, K. ; RODRIGUES, J. C. F. ; RIBEIRO, M.D. ; VILA, T. ; SOUZA, W. ; URBINA, J.A. ; NAKAMURA, C. V. ; ROZENTAL, S. . Growth inhibition and ultrastructural alterations induced by Δ24(25)-sterol methyltransferase inhibitors in Candida spp. isolates, including non-albicans organisms. BMC Microbiology (Online), v. 9, p. 74-85, 2009.
5. ISHIDA, K. ; ROZENTAL, S. ; Mello, J C P ; NAKAMURA, C. V. . Activity of tannins from Stryphnodendron adstringens on Cryptococcus neoformans: effects on growth, capsule size and pigmentation. Annals of Clinical Microbiology and Antimicrobials, v. 8, p. 29-38, 2009.
4. MUSIAL, D. C. ; OLIVEIRA, J. E. ; LIMA, E. L. W. ; ISHIDA, K. ; SCOARIS, D. O. . Frequência de leveduras em exames colpocitológicos oferecidos pelo SUS em duas cidades do norte paranaense. Revista de Biologia e Saúde da UNISEP, v. 4, p. 1-5, 2009.
3. OBICI, S. ; OCTOBONE, F.J. ; SELA, V. R. S. ; ISHIDA, K. ; SILVA, J.C. ; NAKAMURA, C. V. ; CORTEZ, D. A. G. ; AUDI, E.A. . Preliminary toxicity study of dichloromethane extract of Kielmeyera coriacea stems in mice and rats. Journal of Ethnopharmacology, v. 115, p. 131-139, 2008.
2. ISHIDA, K. ; Mello, J C P ; CORTEZ, D. A. G. ; DIAS FILHO, B. P. ; NAKAMURA, T. U. ; NAKAMURA, C. V. . Influence of tannins from Stryphnodendron adstringens on growth and virulence factors of Candida albicans. Journal of Antimicrobial Chemotherapy (Print), v. 58, p. 942-949, 2006.
1. NAKAMURA, C. V. ; ISHIDA, K. ; FACCIN, L. C. ; DIAS FILHO, B. P. ; CORTEZ, D. A. G. ; ROZENTAL, S. ; SOUZA, W. ; NAKAMURA, T. U. . In vitro activity of essential oil of Ocimum gratissimum L. against four Candida species. Research in Microbiology (Paris), Holanda, v. 155, n.7, p. 579-586, 2004.